Crystal structure of AfOgg1-K122S mutant bound to 8-OG DNA duplex in an intermediate state

Crystal structure of AfOgg1-K122S mutant bound to 8-OG DNA duplex in an intermediate state Descriptor: 8-oxoguanine DNA glycosylase/AP lyase, DNA (5'-D(*TP*AP*GP*AP*GP*TP*CP*(8OG)P*AP*CP*CP*TP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*AP*GP*GP*TP*CP*GP*AP*CP*TP*CP*TP*A)-3'), ... Authors: Huffman, J.L, Syed, A, Tang, H.Y.H, Arvai, A.S, Mol, C.D, Tainer, J.A. Deposit date: 2025-04-01 Release date: 2026-04-15 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A unified catalytic mechanism in bifunctional DNA glycosylases with an evolutionarily conserved aspartate-lysine dyad. Nat Commun, 2026