Equations describing the dependence of the volume on the number of atoms/residues lining individual cavities.

aIn the equation y corresponds to the volume (?3) and x to the number of atoms (or residues); the R2 value provides the measure of fit of the power law to the data points. Fitting linear equations provides, for atoms: y = 6.59x�C22.0 (0.90), y = 9.94x�C54.8 (0.94), and y = 7.31x�C26.3 (0.93); for residues: y = 14.74x�C49.5 (0.80), y = 27.08x�C125.4 (0.90), and y = 17.57x�C62.4 (0.86).