Sirena1: The most abundant lncRNA in mouse oocytes brings together post-transcriptional regulations and mitochondrial distribution (rat wild-type GV oocytes)

Long non-coding RNAs (lncRNAs) are a large group of rapidly evolving non-coding RNAs. Tens of thousands of lncRNAs were identified but function has been assigned to relatively few. LncRNAs expressed in mouse oocytes have been annotated but their contribution to oocyte development and early development remains unknown. Here, we report evolutionary history and functional analysis of Sirena1, maternal lncRNA that is the most expressed maternal lncRNA and 10th most abundant Pol II transcript in mouse oocytes.长链非编码RNA（long non-coding RNAs，lncRNAs）是一类数量庞大且快速演化的非编码RNA。目前已鉴定出数万种lncRNAs，但仅极少数被明确了功能。在小鼠卵母细胞中表达的lncRNAs虽已完成注释，但其对卵母细胞发育及早期胚胎发育的贡献仍未明确。本研究针对Sirena1——一种在小鼠卵母细胞中表达量最高的母源lncRNA，同时也是小鼠卵母细胞中丰度位列第10的RNA聚合酶II（RNA polymerase II，Pol II）转录本——开展了演化历史与功能分析，并报道了相关研究结果。