The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog m5(10,8)-(E)-OH

The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog m5(10,8)-(E)-OH Descriptor: (2~{S},9~{S},12~{R},13~{R},14~{E},18~{R})-2-cyclohexyl-18-(hydroxymethyl)-22,23-dimethoxy-12,13-dimethyl-11,17,20-trioxa-4-azatricyclo[19.3.1.0^{4,9}]pentacosa-1(25),14,21,23-tetraene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Meyners, C, Spiske, M, Hausch, F. Deposit date: 2024-09-09 Release date: 2025-01-15 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Conformationally Restricted Macrocycles as Improved FKBP51 Inhibitors Enabled by Systematic Linker Derivatization. Angew.Chem.Int.Ed.Engl., 64, 2025