Flux parameters used in the model.

jijmn represent a flux parameter between a state with i Ca2+ ions and j IP3 molecules and a state with m Ca2+ ions and n IP3 molecules bound. Superscripts are used to distinguish between different flux parameters that connect different pairs of states that have the same numbers of ligands bound. For example, in both transitions C24I⇌O24I and C24H⇌O24H, the channel is bound to the same number of Ca2+ and IP3. However, the two transitions have different flux parameters because the channel is in different gating modes. The same font convention is used for the parameters as in Table 1.