Nono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway [RNA-seq

Purpose: Congenital heart disease (CHD) is the most common type of birth defect and the main noninfectious cause of death during the neonatal stage. Currently, hemizygous loss-of-function variants in NONO(The non-POU domain containing, octamer-binding) gene have been described as the cause of congenital heart defects in males. However, the effects of NONO on cardiac development have not been fully elucidated.研究目的：先天性心脏病（CHD）是最常见的出生缺陷类型，亦是新生儿期非感染性死亡的主要诱因。目前，NONO基因（non-POU domain containing, octamer-binding，含非POU结构域的八聚体结合蛋白）的半合子功能丧失变异已被证实为男性先天性心脏缺陷的致病因素。然而，NONO在心脏发育中的具体作用尚未完全阐明。