Changes in circulating miRNA expression in right heart remodeling due to pulmonary hypertension

Clinical practice currently faces a significant shortfall in specific biomarkers needed for diagnosing right ventricular (RV) remodeling in patients with pulmonary hypertension (PH). MiRNAs are crucial regulators of cardiovascular development, influencing processes like angiogenesis, cardiomyocyte differentiation, cell cycle, cardiac electrical activity, and cardiomyocyte growth. Furthermore, circulating miRNAs are cell-or tissue-specific, relatively stable in serum, and resistant to degradation factors. These properties make serum miRNAs possible promising biomarkers for predictive diagnosis of cardiovascular disease (CVD). This study systematically screened and identified candidate serum miRNAs as potential diagnostic biomarkers for RV remodeling in PH patients.当前临床实践在针对肺动脉高压（pulmonary hypertension，PH）患者右心室（right ventricular，RV）重构的诊断中，所需的特异性生物标志物存在显著匮乏。微小核糖核酸（microRNAs，miRNAs）是心血管发育的关键调控因子，可调控血管生成、心肌细胞分化、细胞周期、心脏电活动以及心肌细胞生长等生物学过程。此外，循环微小核糖核酸具备细胞或组织特异性，在血清中相对稳定且可抵御降解因子的影响。上述特性使得血清微小核糖核酸有望成为心血管疾病（cardiovascular disease，CVD）预测性诊断的潜在生物标志物。本研究系统性筛选并鉴定了候选血清微小核糖核酸，将其作为肺动脉高压患者右心室重构的潜在诊断生物标志物。