Expeditious Total Syntheses of Camptothecin and 10-Hydroxycamptothecin
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https://figshare.com/articles/dataset/Expeditious_Total_Syntheses_of_Camptothecin_and_10_Hydroxycamptothecin/2895241
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资源简介：
New expeditious total syntheses of (S)-camptothecin (16% overall yield, 95% ee) and (S)-10-hydroxycamptothecin (14% overall yield, 99% ee) have been accomplished, respectively, starting from readily available and inexpensive materials. Development, optimization, and successful application of the cascade reaction consisting of a pyrrolidine-catalyzed Michael addition, an intramolecular aldol condensation, and an oxidative aromatization, the intramolecular oxa Diels−Alder cycloaddition, and the Sharpless asymmetric dihydroxylation make these two new syntheses more efficient and straightforward.
创建时间：
2016-02-27
