Whole Genome Bisulfite Sequencing of Autism and Control Human BA9 Cortex

Autism spectrum disorders (ASD), characterized by lack of social and communicative behaviors, have complex etiologies involving multiple genetic and environmental risk factors. Epigenetic information, such as brain DNA methylation patterns, is predicted to reveal insight into the gene networks, cell types, and developmental timing of ASD etiology, but prior methylation studies in ASD have been limited by platform or data integration. Here, we used whole genome bisulfite sequencing (WGBS) to examine DNA methylation genome wide in Brodmann Area 9 of dorsal lateral prefrontal cortex of ASD and Control samples. Overall design: Whole Genome Bisulfite Sequencing of Human BA9 Cortex