Itgav

ENCODES a protein that exhibits signaling receptor binding; C-X3-C chemokine binding (ortholog); collagen binding (ortholog); INVOLVED IN angiogenesis; cell migration; positive regulation of cell population proliferation; PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH Alveolar Bone Loss; Carotid Artery Injuries; Choroidal Neovascularization; FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol

编码一种具有信号受体结合能力的蛋白质；C-X3-C趋化因子结合（同源）；胶原蛋白结合（同源）；参与血管生成、细胞迁移、细胞增殖的正向调控；参与整合素介导的信号通路、血小板衍生生长因子信号通路、鞘氨醇-1-磷酸信号通路；与肺泡骨丢失、颈动脉损伤、脉络膜新生血管形成相关；存在于αv-β3整合素-HMGB1复合物（同源）、αv-β3整合素-IGF-1-IGF1R复合物（同源）、细胞表面（同源）中；与1-萘基异硫氰酸酯、17α-乙炔基雌二醇、17β-雌二醇相互作用。