Gene expression analysis from erythroid progenitors of patients with Diamond-Blackfan anemia

ChEBI2014-02-28 更新2026-07-21 收录

血液病分子机制

血细胞发育基因表达

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-41817 数据链接链接失效反馈

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Gene expression analysis from erythroid progenitors of patients with Diamond-Blackfan anemia

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2014-02-28

Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain

表观遗传调控

血细胞发育基因表达

We have defined the histone acetylation pattern of the endogenous murine β-globin domain, which contains the erythroidspecific β-globin genes. The β-globin locus control region (LCR) and transcription

PubMed Central2000-12-19 更新60

Cell-Autonomous Function of Runx1 Transcriptionally Regulates Mouse Megakaryocytic Maturation

巨核细胞成熟调控

血液病分子机制

RUNX1 transcription factor (TF) is a key regulator of megakaryocytic development and when mutated is associated with familial platelet disorder and predisposition to acute myeloid leukemia (FPD-AML).

NIAID Data Ecosystem30

Genetic disarray follows mutant KLF1-E325K expression in a congenital dyserythropoietic anemia patient. Genetic disarray follows mutant KLF1-E325K expression in a congenital dyserythropoietic anemia patient

血液病分子机制

细胞分化转录调控

Congenital dyserythropoietic anemia (CDA) type IV is caused by a heterozygous mutation, Glu325Lys (E325K), in the KLF1 transcription factor. A molecular understanding of this disease is absent, partly

NIAID Data Ecosystem30

Dysregulation of the Transforming Growth Factor Beta Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia [HTA-2_0]. Homo sapiens

血液病分子机制

细胞疾病模型

Diamond Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome with clinical features of red cell aplasia and variable developmental abnormalities. Most affected patients have heterozygous

NIAID Data Ecosystem50

Small ncRNA expression-profiling of blood from Hemophilia A patients identifies miR-1246 as a potential regulator of Factor 8 gene

血液病分子机制

lncRNA表达调控

Hemophilia A (HA) is a bleeding disorder caused by deficiency of functional plasma clotting factor VIII (FVIII). In addition to genetic mutations in the gene encoding FVIII (F8), there is evidence tha

NIAID Data Ecosystem30

Gene expression analysis from erythroid progenitors of patients with Diamond-Blackfan anemia

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