Exploratory study investigating ocular blood flow in colorectal cancer patients before and after treatment with anti-angiogenic therapy

Primary objectives: It is the primary objective of this study to assess whether there is a change and a correlation between ocular blood flow parameters (retinal vessel diameters, choroidal blood flow, fundus pulsation amplitude, retinal blood velocity and thickness) and treatment response in mCRC treated with standard of care anti-angiogenic regimens in combination with chemotherapy.
Primary endpoints: Retinal vessel diameters using The Retinal Vessel AnalyzerChoroidal blood flow using Laser Doppler flowmetryRetinal blood velocity by laser Doppler velocimeterFundus pulsation amplitude using laser interferometryRetinal thickness by OCT Plasma level of sVEGFR, VEGF, Tie2, intraocular pressure