RNA-seq profiling of colon and ileum tissues from the UC Davis Type 2 Diabetes Mellitus Rat Model

The RNA-seq analysis continues our work profiling the the gastrointestinal tract of the UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rat. Male UCD-T2DM rats (age ~170 days) were included in this study if either recently diagnosed as diabetic (n=6, RD, nonfasting glucose > 300 mg/dl) or 3-month post-onset of diabetes (n=6, D3M). A set of younger non-diabetic UCD-T2DM rats were also studied as a non-diabetic comparison (n=6, ND, age ~70 days).本RNA测序（RNA-seq）分析延续了我们此前针对加州大学戴维斯分校2型糖尿病（UCD-T2DM）大鼠胃肠道开展的谱分析研究。本研究纳入日龄约170天的雄性UCD-T2DM大鼠，分组依据为：要么为近期确诊糖尿病者（非空腹血糖＞300 mg/dl，样本量n=6，记为RD组），要么为糖尿病发病后3个月的大鼠（样本量n=6，记为D3M组）。此外本研究还纳入一组日龄约70天的年轻非糖尿病UCD-T2DM大鼠作为非糖尿病对照（样本量n=6，记为ND组）。