ChIP-seq dataset for epigenomic landscape of MPNST
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https://www.ncbi.nlm.nih.gov/sra/SRP234702
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资源简介：
In order to comprehensively define the epigenetic patterns specific to MPNST, we generated profiles for 6 histone modification marks, including H3K4me1 (enhancer), H3K27Ac (active enhancer), H3K9me3 (heterochromatin), H3K27me3 (polycomb repression), H3K79me2 (transcription) and H3K4me3 (promoter). Systematic epigenomic profiling of chromatin states in MPNST cells revealed epigenetic subtypes in MPNST based on Polycomb related repressive and bivalent chromatin states. We demonstrate that PRC2 loss led to de-repression and subsequent enhancer reprogramming at key neural crest specifiers aiding the acquisition of this de-differentiated aggressive tumor phenotype. Overall design: The dataset contains 5 PRC2 mutant and 4 PRC2 WT MPNST cell lines, 1 NSC sample for 6 histone marks (H3K4me1, H3K9me3, H3K27Ac, H3K79me2, H3K4me3, H3K27me3) and input.
创建时间：
2021-07-23
