Thwarting Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) with Common Bean: Dose- and Sex-Dependent Protection against Hepatic Steatosis

Consumption of beans protects from the development of obesity. We established that dietary bean exerts dose- and sex-dependent effects on the liver transcriptome in the context of lipid metabolism, which prevents the onset of metabolic-associated fatty liver disease. Overall design: C57BL6/J female and male mice were fed isocaloric diets containing 0%, 35%, or 70% of total dietary protein derived from whole-cooked white kidney beans. Total RNA was isolated from their liver tissue samples and subjected to RNA-seq analysis to deduce molecular mechanism of bean effects.