Novel Synthesis of Azepine Derivatives via Copper-Mediated Cyclization of 2-Aza-hepta-2,4-dien-6-ynyl Anions. Intramolecular Addition of Organocopper Centers to the C−C Triple Bond
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https://figshare.com/articles/dataset/Novel_Synthesis_of_Azepine_Derivatives_via_Copper_Mediated_Cyclization_of_2_Aza_hepta_2_4_dien_6_ynyl_Anions_Intramolecular_Addition_of_Organocopper_Centers_to_the_C_C_Triple_Bond/3019099
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资源简介：
Deprotonation of alkynyl imines 1 with LDA at low temperature and subsequent transmetalation with copper thiophenolate gives the annulated
azepines 11a−i in 41−73% yield after aqueous workup. The key step of the reaction is a copper-mediated intramolecular nucleophilic attack
at the triple bond.
创建时间：
2007-03-15
