RhoBTB1 Reverses Established Arterial Stiffness in Angiotensin II Hypertension

We are investigating of role of RhoBTB1 in vascular smooth muscle cells. Restoring RhoBTB1 expression in mouse aorta reversed the established arterial stiffness but not hypertension caused by angiotensin II (Ang-II). To investigate the underlying mechanism by which RhoBTB1 reversed arterial stiffness, we performed bulk RNA-sequencing using aorta from four groups: control /RhoBTB1 transgenic mice treated with/without Ang-II. aortic mRNA profile in vehicle/angiotensin II-treated mice expressing either smooth muscle specific Cre or smooth muscle specific RhoBTB1 transgene.