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Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336

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Protein Data Bank Japan2025-09-17 更新2026-04-19 收录
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Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336 Descriptor: (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... Authors: Lowther, W.T, Gumpena, R. Deposit date: 2023-01-20 Release date: 2024-01-24 Last modified: 2025-09-17 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Characterization of CHK-336, A First-in-Class, Liver-Targeted, Small-Molecule Lactate Dehydrogenase Inhibitor for Hyperoxaluria Treatment. J Am Soc Nephrol, 36, 2025
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2023-01-20
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