Genome wide association study on Labrador retrievers including hip dysplasia and body weight. Labrador hip dysplasia GWAS

Hip dysplasia scores were available for 209 genotyped dogs. After correcting for multiple testing and population structure we identified a significantly associated locus for hip dysplasia on chromosome 24, with three equally associated SNPs (p=4.35x10-7) in complete linkage disequilibrium located within NDRG3, a gene which in humans has been shown to be differentially expressed in osteoarthritic joint cartilage. One of these SNPs is predicted to alter the splice donor site of exon 4 in NDRG3. Body weight at the time of hip dysplasia scoring was available for 85 female dogs which were used as phenotypes for a second genome wide association analysis. After correcting for multiple testing and population structure we identified two significantly associated loci on chromosome 10 (p= 4.48x10-7) and chromosome 31 (p=2.48x10-6).