Chrodrimanins U and V, meroterpenoids from an Alternaria sp.

Two new meroterpenoids, chrodrimanins U and V (1 and 2), and two known compounds 3-hydroxypentacecilide A (3) and chrodrimanin T (4) were obtained from the ascomycete fungus Alternaria sp. Structural characterisation was achieved through integrated spectroscopic techniques. The absolute configuration of each new meroterpenoid (1 and 2) was assigned via ECD calculations, respectively. None of the compounds (1–4) displayed cytotoxicity. In contrast, compounds 1 and 3 exhibited moderate inhibitory activity against H1N1, with IC50 values of 52.2 and 58.4 μM, respectively.