Pathogenesis genes in the highly connected modules that were identified by spectrum partition on the subnetworks formed by pathogenesis genes, receptors, and cytokines, in the context of five immune disorders: rheumatoid arthritis (RA), psoriasis (PS), ulcerative colitis (UC), Crohn’s disease (CD) and systemic lupus erythematosus (SLE).

The table shows that 36 disease genes were identified out of 1,340 disease-associated genes for RA (2.7%), four disease genes from the 542 genes for PS (0.7%), 35 disease genes from the 793 genes for SLE (4.4%), eight disease genes from the 654 genes for UC (1.2%), and 18 disease genes from the 622 genes for CD (3%). Note that many of these disease-associated genes are related to immune responses.