Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ‑Lactones
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https://figshare.com/articles/dataset/Hydrogen_Bond_Directed_Formal_5_1_Annulations_of_Oxindoles_with_Ester_Linked_Bisenones_Facile_Access_to_Chiral_Spirooxindole_Lactones/2313205
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A novel bifunctional thiourea catalyzed formal [5 + 1] cycloaddition of oxindoles and ester-linked bisenones was successfully developed. This strategy involves two sequential Michael additions, leading to spirooxindole δ-lactones with three contiguous stereocenters including an all-carbon quaternary center with high diastereo- and enantioselectivites. In addition, a remarkable N-substituent effect was observed on the reactivity and selectivity.
创建时间：
2016-02-17
