Formation and Conformational Conversion of Flattened Partial Cone Oxygen Bridged Calix[2]arene[2]triazines

A stepwise fragment coupling reaction starting with substituted dichlorotriazine and resorcinol derivatives gave rise to thermodynamically
favored 1,3-alternate tetraoxacalix[2]arene[2]triazines and kinetically controlled flattened partial cone tetraoxacalix[2]arene[2]triazines. The flattened
partial cone conformer, which was stable due to the steric effect, converted into the 1,3-alternate conformer via ether bond cleavage upon
treatment with an inorganic base.

以取代的二氯三嗪和间苯二酚衍生物为起始的逐步片段偶联反应，产生了热力学上优势的1,3-交替四氧杂卡里[2]芳基[2]三嗪及其动力学控制的扁平部分圆锥形四氧杂卡里[2]芳基[2]三嗪。由于立体效应的稳定性，扁平部分圆锥形构象通过无机碱处理发生醚键断裂，转化为1,3-交替构象。