Kinetic parameters for POLRMT-catalyzed nucleotide incorporationa.

aValues rounded to two significant figures. Standard errors are from non-linear regression fits of data to a hyperbolic model (Figures S1, S2 and S3).bmitovir score: rate constant for incorporation calculated by using the experimentally determined kinetic parameters, kpol and Kd,app and the intracellular concentration of nucleoside analog triphosphate [TP] (Table 1); mitovir score = keff (s−1) = (kpol * [TP])/(Kd,app+[TP]).cmitovir score determined for Huh-7 cells.dmitovir score determined for MT4 cells.erate constant for incorporation calculated by using the experimentally determined kinetic parameters, kpol and Kd,app and the intracellular concentration of nucleotide [TP] (Table S1); keff (s−1) = (kpol * [TP])/(Kd,app+[TP]).fnot determined.