Western blot analysis of p53 and Bax in mitochondrial fraction (left) and examination of apoptosis (right) in mouse skin epidermal tissues.

Succinate dehydrogenase subunit B (SDHB) served as the loading control. The levels of p53/Bax were normalized to that of SDHB. Statistical analysis was performed using one-way ANOVA (for multiple group comparison) followed by Newman-Keuls post-test. Ctrl, basal diet; Veh, vehicle control (DMSO); Pro, Protandim. *, p<0.05 when compared to DMBA/TPA group; #, significantly different from Ctrl/TPA.