Effects of Exercise on Cardiovascular Health (STRRIDE)

The STRRIDE study is the combination of three interventional trials to evaluate dose and intensity of physical activity on cardiometabolic health. The three component studies are Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I, ClinicalTrials.gov Identifier: NCT00200993), Effects of Resistence and Aerobic Exercise on Cardiovascular Health (STRRIDE II, ClinicalTrials.gov Identifier: NCT00275145) and Exercise Dose-Response Effects in Prediabetes (STRRIDE-PD, ClinicalTrials.gov Identifier: NCT00962962).]]>
All individuals gave informed consent. The three studies have slightly different inclusion/exclusion criteria; detailed criteria can be obtained from the three ClinicalTrials.gov identifiers (NCT00200993, NCT00275145, NCT00962962). Inclusion Criteria: Age: 45-75 years Moderately overweight determined by Body Mass Index: 25.0 - 35.4 Fasting plasma glucose: > 95 - < 126 mg/dL until 2/15/2012 when lower limit was adjusted to > 100 mg/dL Readings from two separate days, both being > 95 (> 100 after 2/15/2012) and one of the two being < 126 Low density (LDL) cholesterol: < 190 mg/dL Triglycerides: < 600 mg/dL Resting blood pressure: < 160/90 mmHg Inactive: Exercise < one day/week; Peak oxygen consumption: > 18.0 - < 40.0 ml/kg/min until 2/15/2012 when lower limit was adjusted to 12.0 ml/kg/min Medications: Stable use of all medications for > three months Exclusion Criteria: Smoker: Tobacco use within the last 12 months Dieting or intending to diet Use of potential confounding medications, e.g. Niacin containing drugs History of diabetes, heart disease or taking medication for those conditions History of hypertension (high blood pressure) not controlled with medication Pregnant or intending to become pregnant Unwillingness to undergo a three month control/run-in period, be randomized to any one of four intervention groups, submit to thigh muscle biopsies and all other study testing or continuously participate in a randomly assigned exercise training or lifestyle intervention program for six months Orthopedic limitations, musculoskeletal disease and/or injury Allergic to xylocaine (anesthetic or numbing medicine) Inability to give blood continuously through a catheter Unwillingness to exercise at least twice per week at the Duke Center for Living Health and Fitness Center during research study staff supervised times ]]>