Positive effects of bariatric surgery are associated with attenua tion of cellular senescence

Background and aims: Bariatric surgery represents the most efficient approach to treatment of obesity. However, the detailed mechanism of its positive metabolic effect is still not fully understood. Cellular senescence arrests damaged cells thus prevents further spreading of the damage. Persistence of senescent cells especially in adipose tissue can, however, contribute to the development of a number of chronic diseases including obesity and its complications. Reduction of adipose tissue after bariatric surgery can therefore reduce the number of senescent cells and their negative effects on organism.