Pseudomonas mendocina strain:GU Genome sequencing and assembly

Metformin is one of the most widely prescribed pharmaceuticals worldwide. This drug and one of its end products, guanylurea, are not fully metabolized by humans and cannot be completely removed through conventional water treatment procedures. Therefore, these chemicals have accumulated in the environment and have recently been identified as emergent pollutants in surface and wastewaters around the world. This study describes Pseudomonas mendocina GU isolated from a municipal water treatment plant using guanylurea as its sole nitrogen source. The genome was sequenced with 36-fold coverage and mined to identify guanylurea degradation genes.

二甲双胍是全球范围内最广泛使用的药物之一。该药物及其末端产物之一，胍基脲，不能被人体完全代谢，且无法通过常规的水处理程序完全去除。因此，这些化学物质在环境中积累，并最近被确认为全球表面水和废水中出现的新兴污染物。本研究描述了从使用胍基脲作为唯一氮源的城市水处理厂中分离出的假单胞菌属（Pseudomonas mendocina）GU。该菌株的基因组以36倍覆盖率进行了测序，并进行了挖掘，以识别胍基脲降解基因。