Cannabinoid receptor signaling

Endogenous cannabinoid receptors belong to the endocannabinoid system and are located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. The endocannabinoid system is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis. Two primary endocannabinoid receptors have been identified: CNR1 and CNR2. CNR1 is found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC (tetrahydrocannabinol). One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD (cannabidiol). 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management. Source: https://en.wikipedia.org/wiki/Endocannabinoid_system Not all MAPK subtypes are relevant for this pathway. The relevant types have been separately added on the right side of the pathway. Source: Howlett A.C. Cannabinoid Receptor Signaling. In: Pertwee R.G. (eds) Cannabinoids. Handbook of Experimental Pharmacology, vol 168. Springer, Berlin, Heidelberg, 2005

内源性大麻素受体隶属于内源性大麻素系统，分布于哺乳动物大脑及中枢和周围神经系统之中，该系统由神经调节性脂质及其受体构成。内源性大麻素系统参与多种生理过程，包括食欲、痛觉感知、情绪和记忆，并在调节大麻的致幻作用中发挥作用。目前已鉴定出两种主要内源性大麻素受体：CNR1和CNR2。CNR1主要存在于大脑和神经系统，以及外围器官和组织中，是内源性大麻素配体（结合分子）阿纳多胺及其类似物植物大麻素THC（四氢大麻酚）的主要分子靶点。另一种主要内源性大麻素为2-亚麻酸甘油酯（2-AG），它在两种大麻素受体上均具有活性，及其自身类似物植物大麻素CBD（大麻二酚）。2-AG和CBD参与食欲、免疫系统功能和疼痛管理的调节。资料来源：https://en.wikipedia.org/wiki/Endocannabinoid_system。并非所有MAPK亚型与此途径相关。相关类型已分别添加在途径右侧。资料来源：Howlett A.C. 大麻素受体信号传导。在：Pertwee R.G.（主编）大麻素。实验药理学手册，第168卷。Springer，柏林，海德堡，2005。