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Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double-stranded RNA

Mendeley Data2026-04-09 收录

整合应激反应

RNA生物学机制

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Uncropped Images for the research work titled "Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double-stranded RNA"

应用场景：

心肌缺血再灌注损伤

整合应激反应

Under stress conditions, cells elicit integrated stress response (ISR) to cope with intracellular and extracellular disturbances. However, its role in ischemic heart disease remains to be elucidated.

NIAID Data Ecosystem40

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

WEE1抑制剂机制

整合应激反应

The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibition (WEE1i) are largely unknown. A genome-wide inser

NIAID Data Ecosystem30

Determining transcriptome changes in whole spinal cord of YarsE196K mice [19-burgess-002]

周围神经病变转录组

整合应激反应

To determine transcriptome changes in adult spinal cord induced by the YarsE196K mutation. How mutations in broadly expressed housekeeping genes lead to neurodegeneration in specific cell types remain

NIAID Data Ecosystem20

Exploring the in vivo role of the mitochondrial calcium uniporter in brown fat bioenergetics. Exploring the in vivo role of the mitochondrial calcium uniporter in brown fat bioenergetics

棕色脂肪产热

整合应激反应

The mitochondrial calcium uniporter has been proposed to coordinate the organelle’s energetics with cytosolic calcium signaling. Previous studies have shown that the uniporter current is extremely hig

NIAID Data Ecosystem30

Gene expression in mouse white adipose tissue

脂肪组织基因表达

整合应激反应

Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT). The early transcriptome changes in WAT were analyzed using high-density microarrays to bette

NIAID Data Ecosystem30

Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double-stranded RNA

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