The BPMS is a significant predictor of metastasis-free survival (MFS) after adjustment for 7 other prognostic gene signatures.

Multivariate cox models for prognostic signatures. Survival data was fit in the BrCa443 validation set against the 7 combined signatures in a multivariate Cox proportional hazards model. Similarly, the same data was fit in the BrCa443 set against the 7 combined signatures including the BPMS. B) Likelihood ratio test for competitive models. Using the likelihood of the multivariate models, an analysis of variance (likelihood ratio test) demonstrates that the BPMS selects a cohort of patients independent of all other gene signatures (p = 0.028, χ2 = 4.8, df = 1). A)