Occupancy of synaptonemal complex at mouse genome

As the vital components of synaptonemal complex, SYCP3 plays an important role in meiosis by self-assembling into a special bilayer structure. Although SYCP3 has been widely studied, the genome-wide binding of SYCP3 remains largely unknown. In this study, we identified specific binding of SYCP3 in mouse spermatocytes and studied how its binding dynamics is regulated. Mouse spermatocytes were collected from male mouse testis, followed by ChIP-seq assay to identify specific protein occupancy.