High altitude adaptation of domestic mammals in Tibet. Laurasiatheria

Domestic mammals are believed to facilitate permanent occupation of humans to “roof of the world”, Tibetan Plateau, and have been commonly raised by Tibetans. These young breeds (< ~4000 years old) provide as the materials for insight into the evolution of high altitude adaptation, which is crucial for the livestock husbandry in Tibet but largely remain undocumented. Here, we employed comparative population genomics to identify the genetic mechanism underlying the high altitude adaptation of Tibetan horse, sheep, goat, cattle, pig and dog.