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Differential microRNA profiles associated with the hydroxyurea-inducible SAR1A gene

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295109
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We used small-RNA sequencing to carry out the first comprehensive survey of miRNAs expressed in SAR1A-knockout K562 cells without or with HU treatment and assessed their potential functions related to HbF induction. our findings suggest a profile of dysregulated miRNAs associated with SAR1A downregulation which may influence HbF expression directly or indirectly targeting the transcription factors linked to gamma-globin gene regulation. small RNA-Seq profiling of wildtype K562 cells and SAR1A-knockout K562 cells without or with HU treatment
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2025-09-22
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