Study of attenuation of Infectious Bronchitis virus during live attenuated vaccines virus production

NIAID Data Ecosystem2026-03-13 收录

病毒减毒工艺

兽用疫苗质量控制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA795093 数据链接链接失效反馈

官方服务：

资源简介：

Attenuation of IBV M41-CK in 100 consecutive passages of eggs

创建时间：

2022-01-06

Data_Sheet_1_Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility.PDF

抗原表位定位

兽用疫苗质量控制

Vaccination with intact (146S) foot-and-mouth disease virus (FMDV) particles is used to control FMD. However, 146S particles easily dissociate into stable pentameric 12S particles which are less immun

NIAID Data Ecosystem460

Quality Control testing of bulk NOMV.

兽用疫苗质量控制

免疫原性

A) General characteristics include biochemical composition, PorA identity, and sterility for which preliminary specifications were set. B) Endotoxic activity of the bulk NOMV was approximately 25-fold

NIAID Data Ecosystem90

Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid

蛋白质组学定量

兽用疫苗质量控制

Currently, animal tests are being used to confirm the potency and lack of toxicity of toxoid vaccines. In a consistency approach, animal tests could be replaced if production consistency (compared to

NIAID Data Ecosystem80

小反刍兽疫活疫苗病毒含量测定方法

兽用疫苗质量控制

生物技术

小反刍兽疫活疫苗中的病毒含量高低，与疫苗产品的质量密切相关。小反刍兽疫病毒接种Vero细胞以后，经过一定时间培养后可以产生明显的细胞病变（CPE）。将小反刍兽疫活疫苗经过一系列稀释后接种Vero细胞，连续培养后根据产生的细胞病变孔数可以计算出疫苗中病毒含量（TCID50）。

国家地球系统科学数据中心2018-01-21 更新110

禽网状内皮组织增生症病毒（REV）检验法

病毒检测

兽用疫苗质量控制

借鉴《欧洲药典》、《英国药典（兽药）》和《日本农林水产省兽医生物制品标准》对禽源活疫苗种毒和生产原材料（SPF鸡胚）以及成品中污染REV的检测方法，建立了禽用病毒类活疫苗中污染REV的间接免疫荧光（IFA）检测法。

国家地球系统科学数据中心2018-01-21 更新80