Transcription profiling of mouse metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice using the NIA 22K 60-mer oligo microarray.卵母细胞（oocyte）功能随母体衰老而下降，是人类不孕症的主要致病因素之一。为探究小鼠模型中年龄依赖性的分子变化，本研究采用NIA 22K 60-聚体寡核苷酸微阵列（NIA 22K 60-mer oligo microarray），对比了5~6周龄小鼠与40~42周龄小鼠所采集的减数分裂II期卵母细胞（metaphase II oocytes）的基因表达谱。