BindingDB Entry 50046414: Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.

Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, ALK tyrosine kinase receptor, Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase, Aurora kinase B/Inner centromere protein, Cyclin-Dependent Kinase 2 (CDK2), Cytochrome P450 2B6, Cytochrome P450 2D6 (2D6), Dual specificity protein kinase TTK, Ephrin type-A receptor 2, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2), IGF-like family receptor 1, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, JAK2/TYK2, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, MAP kinase ERK2, MAP kinase signal-integrating kinase 2, MAP kinase-activated protein kinase 2, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase 14, Mitotic checkpoint serine/threonine-protein kinase BUB1, Neurotrophic tyrosine kinase receptor, PKC alpha and beta-2, Pancreatic endoplasmic reticulum kinase (PERK), Platelet-derived growth factor receptor beta, SRC, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase EEF2K, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase NIM1, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase tousled-like 2, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BRK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Vascular endothelial growth factor receptor 2, cAMP-dependent protein kinase (PKA), and poly-ADP-ribose polymerase 1 (PARP1), Uniprot O00311, O00418, O14757, O14920, O14965, O15530, O43683, O60674, O96013, P00519, P00533, P04629, P05771, P06213, P06239, P07948, P07949, P08581, P09619, P09874, P10635, P10721, P11309, P11362, P17612, P20248, P20813, P23458, P24941, P28482, P29317, P29597, P31749, P33981, P35968, P36888, P43403, P43405, P49137, P49841, P52333, P53350, Q05397, Q07912, Q13882, Q14680, Q16539, Q86UE8, Q8IY84, Q8TF76, Q96GD4, Q9H665, Q9HBH9, Q9HC98, Q9NZJ5, Q9P1W9, Q9P289, Q9UBU7, Q9UGN5, and Q9UM73