CryoEM structure of GNE-1952-alkylated KRAS G12C in complex with engineered conformationally rigid Fab 2H11.4DS

CryoEM structure of GNE-1952-alkylated KRAS G12C in complex with engineered conformationally rigid Fab 2H11.4DS Descriptor: 1-{4-[(7M)-6-methyl-7-(5-methyl-2H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, Fab 2H11.4DS heavy chain, Fab 2H11.4DS light chain, ... Authors: Kung, J.E, Sudhamsu, J. Deposit date: 2023-12-27 Release date: 2024-10-30 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Disulfi de constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM. Biorxiv, 2024