A single cell immune cell atlas of human hematopoietic system

Human hematopoiesis is essential for producing blood cells and maintaining a healthy immune system. To provide a single-cell level characterization of the hematopoietic system, we profiled cells collected from cord blood, adult peripheral blood and adult bone marrow, to produce an immune cell atlas consisting of 1,453,784 single cells. Our atlas consists of a variety of single-cell RNA-seq assay types, such as standard assay, genetic pooling and cell hashing, which makes it an ideal dataset for benchmarking and developing new demultiplexing algorithms. We anticipate that our data will play an important role in addressing key questions of the human hematopoietic system, facilitating design of novel complete blood cell count tests and shedding light on new drug development as a health reference.