Duration of each line of treatment.

Figures in brackets represent lower and upper quartile limits.Abbreviations: ADAP: Antidepressant and antipsychotic/antimanic drugs; p = p-value; H0 = Null Hypothesis, H1 = Alternative Hypothesis; MT = the average duration of a LOT in TRD episodes, MN = the average duration of a LOT in non-TRD episodes; LOT = Line of therapy.aAn episode will have at least 3 lines of treatment to qualify as TRD, based on the definition stated in the Methods section.