Human striatal glia differentially contribute to AD and PD-specific neurodegeneration

Alzheimer disease (AD) and Parkinson disease (PD) are the two most common forms of neurodegenerative diseases without effective disease modifying treatments. Despite decades of intensive research, the molecular mechanism of neurodegeneration remains uncertain. We performed the first single-nucleus transcriptome comparison between AD and PD brains. Overall design: We selected 4 cases with pathological hallmarks of AD, 4 cases diagnosed with PD, and 4 control cases without AD or PD pathology and performed single-nucleus transcriptome comparison using the 10X Genomics platform.