Single-cell RNA sequencing in HBV-associated cirrhosis

Liver cirrhosis is a significant global health burden. However, its exact mechanisms remain incompletely established. Four HBV-related cirrhotic and three normal liver tissues were obtained for single-cell RNA sequencing. Based on multiple intrahepatic cell populations, the human single cell atlas of HBV-associated cirrhosis was established in this study, in an attempt to reveal the characteristic changes of different cell populations during the development of HBV-associated cirrhosis, and to elucidate the unknown features of cirrhosis that could not be recognized in traditional transcriptome studies.