Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Comparison of Clinical and Biological Responses to Cat Allergen

A direct comparison of NAC and EEC allergen challenges revealed differences in the kinetics and magnitude of clinical responses, but comparable immunological responses indicating similarity in the biological pathways elicited by both challenge methodologies Nasal brushing samples collected from ITN cat allergic individuals at baseline (prior to allergen exposure), 8 hours after nasal allergen challenge (NAC) exposure, and 8 hours after environmental exposure challenge (EEC). Cross over study design