COMPARATIVE EFFECTS OF AMYLASE ADMINISTRATION INTO THE DUODENUM AND THE ILEUM

This urgent adaptation is also manifested in the characteristic set of enzymes in the secretion released in response to each type of food. In ensuring rapid adaptations of the secretory activity of the pancreas to the type of food consumed, corrective influences on the gland originating from the duodenum are of great importance, depending on the composition and properties of its chyme. Receptors, and especially endocrine cells of the mucous membrane of the duodenum, respond to many components of the duodenal contents, including the presence of pancreatic secretions. The inhibition of pancreatic secretion is associated with the action of pancreatic proteinases and products of proteolysis on the mucous membrane of the duodenum and its endocrine apparatus. The role of other pancreatic juice hydrolases has been insufficiently studied, and only a few studies have addressed this issue. The presence of such influences would allow a more complete understanding of the subtle adaptations of pancreatic secretion based on the corrective effects of the duodenum on the pancreas, not only through positive stimulating influences but also through negative inhibitory ones.