Combination index of tenovin-6 plus docetaxel, SN-38, cisplatin, and 5-FU in gastric cancer cells.

The cytotoxic effects of combining docetaxel, SN-38, cisplatin, and 5-FU with tenovin-6 were determined by isobologram. Combination index (CI) >1.3, antagonism; CI  = 1.1–1.3 moderate antagonism; CI  = 0.9–1.1 additive effect; CI  = 0.8–0.9 slight synergism; CI  = 0.6–0.8 moderate synergism; CI  = 0.4–0.6 synergism; and CI  = 0.2–0.4 strong synergism. Bold and italic numbers indicate synergistic effects. †: NUGC-3 was treated at 0.5 µM cisplatin.