Adult Neurogenesis of the Median Eminence Contributes to Structural Reconstruction and Recovery of Body Fluid Metabolism in Hypothalamic Self-Repair

Purpose: To investigate the underlying regulatory mechanism of neurobiology induced by hypothalamic injury from basic gene expression profile, we extracted RNA from hypothalamic median eminence (ME) RNA sequencing (RNA-seq), at day 1 after control and PEL surgery. Results: We identified 811 differentially expressed genes (DEGs, defined as adjust p value < 0.05) between PEL_1d (day 1 after PEL) and control group. Conclusions:We revealed that RNA-seq based transcriptome characterization would expedite genetic network analyses of hypothalamic ME and permit the dissection of complex biologic functions during the process of central diabetes insipidus after PEL surgery. Hypothalamic ME mRNA profiles of Control and PEL_1d rats.