Bias of lineage-frequency estimates.

The figure shows the relative bias in % of the BCMLE (plots on the right in each panel) and the MLE (plots on the left in each panel) of lineage frequencies p as a function of the true parameter ψ based on simulated data created by the conditional Poisson model. Each panel assumes a different lineage-frequency distribution p shown at the top of each panel. In panel A, the relative bias in % of only one lineage frequency is illustrated, because all lineage frequencies are equal and their relative bias is almost identical. Different rows in panel B correspond to different lineage frequencies. Each colored line corresponds to a different sample size N. (ZIP)