Regorafenib in combination with metronomic cyclophosphamide, capecitabine, and low-dose aspirin in metastatic colorectal cancer carcinomaAn open-label phase II

Primary objectives: The main objective of this clinical trial is to assess the potential clinical interest of regorafenib in combination of metronomic chemotherapies and low-dose aspirin in patients with metastatic colorectal cancer carcinoma, previously exposed or not considered as candidate for 5FU, CPT11, oxaliplatin, anti-VEGF and anti-EGFR, by evaluation of the objective response rate (ORR) during treatment period
Primary endpoints: The objective response rate (ORR) will be defined by RECIST v1.1 criteria (Annex 2) as the best disease response observed during the treatment period. ORR rate is defined as the proportion of patients whose tumor regresses or does not progress under treatment.