Prmt6 promotes glycolysis and osteoclastogenesis by regulating histone epigenetic modification.

Metabolic reprogramming has a critical role in osteoclastogenesis, in which the mechanisms remain elusive. Here, we discovered that Prmt6 acts as a novel regulator of metabolic reprogramming in osteoclastogenesis. In order to study the mechanism by which Prmt6 promotes osteoclastogenesis, ATAC-seq was performed on Prmt6+/+ and Prmt6-/- bone marrow monocytes (BMMs) before and after 12-hour stimulation of M-CSF (50 ng/ml) and RANKL (100 ng/ml). The results indicated that Prmt6-deficient pre-osteoclasts exhibited reduced glycolysis.