Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent

transcriptional profiling was performed on Regnase-1 KO CAR and Regnase-1 TCF-1 DKO CAR T cells isolated 7days after co-transfer into tumor bearing mice. TCF-1 deficiency in Regnase-1 KO CAR T cells led to reduced long-term persistence and memory-like phenotype. In total 10 samples were analyzed: (KO CAR n=5; DKO CAR n=5)